Top articles picks

Keeping up with the literature is a challenge everyone in the science faces. In January 2021, ECNP launched a new initiative to help the ECNP community by bringing them the most important new papers in each of the field’s key subject-matter areas.

Cell culture and live cell imaging

• Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids.
  Sawada T et al., Mol Psychiatry, November 2020.
  Recommended by Edna Grünblatt, Switzerland. ''This paper demonstrates nicely how this platform can help in advancing the neuropsychopharmacology field.''

Biostatistics and computational methods

• Brain Connectome Mapping of Complex Human Traits and Their Polygenic Architecture Using Machine Learning.
  Maglanoc LA et al., Biol Psychiatry, April 2020.
  Recommended by Florian Freudenberg, Germany. ''I propose this paper that describes a machine learning approach to map and correlate the connectome of different phenotypic traits and respective polygenic scores. It also covers cross-disorder aspects as well as neuroimaging, machine learning and genetics.''

In vivo neuroimaging

• Cross-Disorder Analysis of Brain Structural Abnormalities in Six Major Psychiatric Disorders: A Secondary Analysis of Mega- and Meta-analytical Findings From the ENIGMA Consortium.
  Opel N et al., Biol Psychiatry, November 2020.
  Recommended by Florian Freudenberg, Germany. ''This article investigates correlation of structural abnormalities in a cross-disorder approach.''
       
• The genetic architecture of the human cerebral cortex Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group.
  Science, March 2020.
  Recommended by Guido van Wingen, The Netherlands. ''The authors show that ~30% of the variation in the anatomy of the human cerebral cortex can be explained by common genetic variants, and that the variation in cortical structure is genetically associated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.''

Mood disorders

• An electroencephalographic signature predicts antidepressant response in major depression.
  Wu et al., Biotechnol, April 2020.
  Recommended by Guido van Wingen, The Netherlands. ''This paper shows that an EEG signature can predict the response to sertraline for individual patients with depression. Patients with a low estimated sertraline response showed a beneficial response to transcranial magnetic stimulation (TMS), suggesting that this EEG signature may be used for treatment selection.''

Other topics

• Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
  Paul Bastard et al., Science, October 2020. 
  
• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
  Zhang et al., Science, October 2020.
  Both articles are recommended by Florence Thibaut, France. "These two papers may partly explain the mortality ratio differences between men and women''.